Over 800 hectares (nearly 2,000 acres) have been ravaged by the fire in the mountains between the historic cities of Lucca and Pisa.
"Around 3,500 people are affected," the municipality of San Giuliano Terme said in a statement.
"The wind ... has pushed the flames further downhill" towards the village of Asciano, it said.
READ ALSO: Italy's wildfire season starts early as hot, dry May forecast for south
The statement said that three Canadair water-dumping planes and a helicopter were dousing the wildfire.
It added that there were 19 fire brigade vehicles and army and police were assisting with the evacuation.
Two gyms in the area equipped to put up evacuees were housing around 107 people, the statement said.
Wildfires are common in Italy, but usually in the summer months yet to come -- although the season has been starting earlier because of rising temperatures.
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